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Saturday, July 25, 2020 | History

2 edition of Genetical aspects of abnormal sperm production in mice. found in the catalog.

Genetical aspects of abnormal sperm production in mice.

Alida Petronella Hugenholtz

Genetical aspects of abnormal sperm production in mice.

by Alida Petronella Hugenholtz

  • 355 Want to read
  • 19 Currently reading

Published .
Written in English


The Physical Object
Pagination138 leaves
Number of Pages138
ID Numbers
Open LibraryOL14379495M

Unique for its role in human reproduction, a gamete is a specialized sex cell carrying 23 chromosomes—one half the number in body cells. At fertilization, the chromosomes in one male gamete, called a sperm (or spermatozoon), combine with the chromosomes in one female gamete, called an oocyte. The function of the male reproductive system is to produce sperm and transfer them to the . The percentages of normal and abnormal spermatozoa are shown in Table 3. Morphological analysis of semen samples revealed a significant lower percentage of sperm-atozoa with normal morphology in all experimental groups (Psperm with abnormal head in group B were by:

  It is characterized by abnormal sperm and leads to an inability to father biological children (infertility). In affected males, almost all sperm cells have abnormally large and misshapen heads. The head of the sperm cell contains the male's genetic information that is .   Using a sample of freeze-dried mouse sperm, the team was able to produce a litter of healthy baby mice. As part of a fertility study, the mouse sperm had spent nine months aboard the.

  If DNA is the cookbook that cells can use to "build" your body, epigenetics is the cook that helps the body read and mix together our genetic recipe. Epigenetics is the study of how external and environmental factors can impact our DNA’s gene expression without changing the DNA itself. New research shows that epigenetic markers on sperm can assess risk for male factor infertility and poor. For men with sperm counts of 10 to 20 million/mL and no endocrine disorder, clomiphene citrate (25 to 50 mg po once/day taken 25 days/mo for 3 to 4 mo) can be tried. Clomiphene, an antiestrogen, may stimulate sperm production and increase sperm counts. However, whether it improves sperm motility or morphology is unclear, and it has not been.


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Genetical aspects of abnormal sperm production in mice by Alida Petronella Hugenholtz Download PDF EPUB FB2

The results suggest that sperm abnormalities might provide a rapid inexpensive mammalian screen for agents that lead to errors in the differentiation of spermatogenic stem cells in vivo and thus indicate agents which might prove to be mutagenic, teratogenic, or by: Abstract.

In this chapter I shall review evidence for direct genetic control of spermatogenesis in mice from two perspectives. First, I shall consider genetic conditions affecting the process of spermatogenesis: both specific gene mutations and chromosome anomalies causing interruption of Cited by: Mice lacking the centromere protein B exhibit a phenotype which is very similar to that of the Arl4-null mutant.

Centromere protein B is a DNA binding protein required for meiosis; its deletion caused a reduction in testis weight by 30% and reduction in the sperm count by 40% without a reduction in by: Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility.

J Clin Endocrinol Metab ; – [] Dowsing AT, Yong EL, Clark M, et by: Mice born after the microinjection of sperm small RNA of CNT or infected (Tg) mice were assessed for behavioral changes at adulthood. (A) In male mice, object recognition memory was assessed by calculating the time spent by mice exploring a novel and a familiar object 24 h after training and represented as percentage of object preference.

Mutation Research, () 1 Elsevier Biomedical Press An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals A report of the U.S. Environmental Protection Agency Gene-Tox Program * Andrew J.

Wyrobek a, Laurie A. Gordon a, James G. Burkhart b Mary W. Francis c, Robert W. Kapp Jr. d, Gideon Letz e, Heinrich V. Malling b, John C. Topham f and Cited by: Adult male mice had the posterior halves of their bodies exposed at 44 W/kg a waveguide system to GHz microwave radiation for 30 min.

They were killed sequentially over 10 weeks and assessed for decreased sperm count and abnormal sperm morphology.

The response in each assay was maximal 2–4 weeks after the by: The values for the number of spermatids per testis and spermatids per gram of tissue are divided byrespectively, to obtain daily sperm production (per testis) and efficiency of sperm production (per gram testis) (vom Saal et al.

Measurements of epididymal sperm count: One whole epididymis is weighted and homogenized. Sperm are. Table 1, Table 2 record the data obtained for the number and percentages (mean ± S.E.) of abnormal sperm and different types of abnormal sperm heads induced by ml olive oil (vehicle control) and 8, 16 and 32 μl/kg b.w.

of crotonaldehyde (transbutenal) after 1, 3 and 5 weeks of percentage of sperm showing abnormal head morphology in animals treated with ml olive oil Cited by: Epididymal sperm concentration, motility and abnormal sperm.

The mice were sacrificed by cervical dislocation. The epididymes were excised and placed in a prewarmed petri dish containing 1 ml phosphate buffered saline (PBS, pH ) at 37 °C and placed in a 37 °C incubator for 15 min, prior to determining sperm by: Among them, teratozoospermia is characterized by the presence of spermatozoa with abnormal morphology over 85 % in sperm.

To be considered as morphologically normal, a spermatozoon should have a normal acrosome, an oval head between 5 and 6 μm long and and μm width, a midpiece of to μm and a tail or flagellum about 50 μm Cited by:   Bal R Türk G Yilmaz O Etem E Kuloğlu T Baydas G Naziroğlu M.

Effects of clothianidin exposure on sperm quality testicular apoptosis and fatty acid composition in developing male rats. Cell Biol Toxicol ; doi: /s Quinto I De Marinis E. Effects of propineb and dowther A on sperm morphology in by: 9. Abnormal sperm production is one of the leading causes of male infertility.

Approximately one in three infertile males experience a blocking or severance of the ms with producing spermMale infertility has two common causes and names:Azoospermia, where no sperm cells are producedOligospermia, where fewer than normal sperm cells aresperm cells can be.

In recent years, the identification of infertility genes spanning all aspects of spermatogenesis, sperm maturation, capacitation and fertilization has been accelerated by mouse model studies.

4, 50, 51, 52 At least fertility essential genes have been modeled in mice. The majority of these genes were identified using knockout models and to a lesser extent, knockin, Cited by: Genetic disorders in men affect the production of sperm and sexual development in general.

For example: Kallman syndrome also affects men and results in low levels of testosterone, LH, and FSH, the hormones responsible for fertility. Genetical and ultrastructural aspects of the immotile-cilia syndrome. Abstract. The immotile-cilia syndrome is a congenital disorder characterized by all cilia in the body being either immotile or showing an ineffective beating pattern.

Bryan JH. Spermatogenesis revisited. Abnormal spermiogenesis in mice homozygous for another male Cited by: WHO laboratory manual for the examination and processing of human semen - 5th ed. Previous editions had different title: WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction.

- chemistry. - laboratory manuals. tozoa - laboratory manuals. count. The aim of this study was to determine the effects of quercetin on inducing abnormal sperm morphology in mice. 11, week old mice (CFW × C57BL) F1 received a single injection of quercetin. Making sense of the Semen analysis report.

Sperm Count, Sperm Motility, Sperm Morphology. Free Online Books. Free Email Consultation for IVF. (even a flu or a fever can temporarily depress sperm counts) If the sperm test is abnormal, this will need to be repeated times over a period of months to confirm whether the abnormality is.

what causes abnormal sperm production. In approximately one in three cases, male infertility occurs due to the absence of tubes or blockages – which occurs because of vasectomy or injury. It is only in rare cases that a genetic disease like chromosomal abnormality or cystic fibrosis can trigger male infertility.

Reproduction in the mature female mouse consists of a series of related and dependent hormonal and neural events which function to insure the successful production of new members of the species. Basic in this process is the interaction of the anterior pituitary, placental, and gonadal hormones.Abnormal sperm is a very severe problem and it is nothing like low sperm count or low motility of the sperm.

Low sperm count can be corrected in more ways than one. Some of these ways are extremely simple such as wearing boxers instead of briefs and following a healthy lifestyle.

Claim Your 20 Free [ ].Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules.

These cells are called spermatogonial stem mitotic division of these produces two types of cells. Type A cells replenish the stem cells, and MeSH: D